<rdf:RDF
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:ns5="http://nbrp.jp/ontology/"
    xmlns:ns1="http://metadb.riken.jp/db/rikenbrc_mouse/"
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    xmlns:ns11="http://purl.org/net/cito/"
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    xmlns:ns4="http://metadb.riken.jp/terms/xsearch#"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:ns9="http://purl.obolibrary.org/obo/"
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    xmlns:skos="http://www.w3.org/2004/02/skos/core#"
    xmlns:ns7="http://semanticscience.org/resource/"
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  <rdfs:Class rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC00757">
    <rdfs:subClassOf rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/Strain"/>
    <foaf:depiction rdf:resource="https://mus.list.brc.riken.jp/ja/wp-content/image_s/00757-P-215-02.jpg"/>
    <ns1:colonyMaintenance xml:lang="en">Homozygous mutant mice were viable and fertile.</ns1:colonyMaintenance>
    <ns1:genotypingProtocol rdf:resource="http://mus.brc.riken.jp/DataSheet/pcr00757"/>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC00757"/>
    <ns6:brs_depositedBy rdf:parseType="Resource">
    </ns6:brs_depositedBy>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr00757'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
    <ns6:brs_hasAppearance rdf:parseType="Resource">
    </ns6:brs_hasAppearance>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns6:brs_depositorOrganization xml:lang="en">Nagoya Univ.</ns6:brs_depositorOrganization>
    <skos:altLabel xml:lang="ja">HePTP Knockout mice</skos:altLabel>
    <skos:altLabel xml:lang="en">HePTP Knockout mice</skos:altLabel>
    <rdfs:label xml:lang="en">B6;129P2-Ptpn7&lt;tm1Bwz&gt;/Rbrc</rdfs:label>
    <rdfs:label>B6;129P2-Ptpn7&lt;tm1Bwz&gt;/Rbrc</rdfs:label>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
    <ns6:brs_geneticBackground rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/geneticBackground_5"/>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <dc:description xml:lang="ja">血球系細胞に特異的に発現するチロシンフォスファターゼ (HePTP) の遺伝子をジーンターゲテイングにより破壊した。このノックアウトマウスは正常に発育するが、脾細胞の刺激時におけるERKの活性化が強く見られると言う特徴がある。</dc:description>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/11564869"/>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns4:termsAndConditions xml:lang="en">No specific terms and conditions.    (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)</ns4:termsAndConditions>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_4"/>
    <ns1:ESCellLine>E14K [129P2/OlaHsd]</ns1:ESCellLine>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/11564869"/>
    <ns1:colonyMaintenance xml:lang="ja">特に問題なし。繁殖効率：A</ns1:colonyMaintenance>
    <dcterms:identifier>RBRC00757</dcterms:identifier>
    <foaf:depiction rdf:resource="http://ja.brc.riken.jp/lab/bpmp/use_photo/mouse/00757.jpg"/>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:2178956"/>
    <ns6:brs_depositor xml:lang="ja">鈴木　治彦</ns6:brs_depositor>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://profs.provost.nagoya-u.ac.jp/html/100001264_en.html" target="_blank"&gt;Contact Information&lt;/A&gt;</ns4:addinfo>
    <ns6:brs_depositor xml:lang="en">Haruhiko SUZUKI</ns6:brs_depositor>
    <ns1:colonyMaintenance xml:lang="ja">特に問題なし。 繁殖効率：A</ns1:colonyMaintenance>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns6:brs_depositorOrganization xml:lang="ja">名古屋大学</ns6:brs_depositorOrganization>
    <ns1:strainDevelopment xml:lang="ja">1994年にカナダ・オンタリオ癌研究所・T.W Mak研究室において、鈴木治彦先生の手によって作製された。</ns1:strainDevelopment>
    <dc:description xml:lang="en">Developed by Dr. Haruhiko Suzuki, University of Toronto in 1994.  A neomycin selection cassette was inserted into the second exon of the HePTP gene.  The HePTP deficient mice were backcrossed to C57BL/6 for 4 times.</dc:description>
    <ns9:RO_0002162 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
    <ns1:strainDevelopment xml:lang="en">B6;129P2-Ptpn7&lt;tm1Bwz&gt;.  Hematopoietic protein tyrosine phosphatase (HePTP) is a hematopoiesis-specific cytoplasmic protein tyrosine phosphatase that is induced in primary lymphocytes by extracellular stimuli.  This knockout mouse strain is useful for investigating the function of the HePTP gene.</ns1:strainDevelopment>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_targeting"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <ns1:donorDNA>herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Ptpn7 genomic DNA</ns1:donorDNA>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns5:organism rdf:parseType="Resource">
    </ns5:organism>
    <ns4:termsAndConditions xml:lang="ja">条件を付加しない。</ns4:termsAndConditions>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_8"/>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
  </rdfs:Class>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RecoveryTestResult_156">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC00757"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014853">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC00757"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001248">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC00757"/>
  </rdf:Description>
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